The ubiquitin proteasome system (UPS) is the major non-lysosomal, intracellular proteolytic system. Its main role is the recycling of cellular components. The UPS is also important in the quality control of proteins, control of cell cycle, transcription factor regulation, cell differentiation and immune response…

Read More

Chile is a country with a huge biotechnological potential. In our lab, we exploit the optimal conditions for camelid maintenance and its peculiar immune system to develop and produce recombinant antibody fragments of alpacas, known as Nanobodies (Ablynx). Over the last year, we have implemented a laboratory for camelid biotechnology at the Austral University of Chile…

Read More

In our laboratory we commonly use CRISPR/CAS9 methods for the generation of Knock-out genes and also gene edition in cells. We have standardized methods for gRNA generation and introduction of genetic material into specific locations in the genome.

Together with Dr. Gopal Sapkota, we developed a rapid method for the introduction of the firefly luciferase under the control

Read More