Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains.

Lopez-Guerrero AM, Tomas-Martin P, Pascual-Caro C, Macartney T, Rojas-Fernandez A, Ball G, Alessi DR, Pozo-Guisado E, Martin-Romero FJ.

Sci Rep. 2017 Mar 24;7(1):383. doi: 10.1038/s41598-017-00331-4.



Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV.

FASEB J. 2017 Jun;31(6):2446-2459. doi: 10.1096/fj.201600713R. Epub 2017 Mar 2.



An affinity-directed protein missile system for targeted proteolysis.

Fulcher LJ, Macartney T, Bozatzi P, Hornberger A, Rojas-Fernandez A, Sapkota GP.

Open Biol. 2016 Oct;6(10). pii: 160255.



Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.

Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay RT, Sapkota GP.

Sci Rep. 2015 Apr 29;5:9811. doi: 10.1038/srep09811.




SUMO chain-induced dimerization activates RNF4.

Rojas-Fernandez A, Plechanovová A, Hattersley N, Jaffray E, Tatham MH, Hay RT.

Mol Cell. 2014 Mar 20;53(6):880-92. doi: 10.1016/j.molcel.2014.02.031.



Previous work


Turning the RING domain protein MdmX into an active ubiquitin-protein ligase.

Iyappan S, Wollscheid HP, Rojas-Fernandez A, Marquardt A, Tang HC, Singh RK, Scheffner M.

J Biol Chem. 2010 Oct 22;285(43):33065-72. doi: 10.1074/jbc.M110.115113. Epub 2010 Aug 12.


Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1.

Núñez MT, Tapia V, Rojas A, Aguirre P, Gómez F, Nualart F.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C477-85. doi: 10.1152/ajpcell.00168.2009. Epub 2009 Dec 9.


Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells.

Arredondo M, Tapia V, Rojas A, Aguirre P, Reyes F, Marzolo MP, Núñez MT.

Biometals. 2006 Aug;19(4):379-88.


Hereditary hemochromatosis: an opportunity for gene therapy.

Ezquer F, Núñez MT, Rojas A, Asenjo J, Israel Y.

Biol Res. 2006;39(1):113-24.


Antioxidant responses of cortex neurons to iron loading.

Aguirre P, Mena N, Tapia V, Rojas A, Arredondo M, Núñez MT.

Biol Res. 2006;39(1):103-4.