The major interest of our group focuses is the study of post-translational modifications. In particular proteins what covalently attached other proteins covalently. This family of proteins is known as Ubiquitin-like proteins mayor player on the Ubiquitin Proteasome system.
Objectives of our laboratory
The covalent modification of proteins constitutes an emergent level of regulation. When a modificiation occurs the substrate and the modification converge into a new component, we could say a new spatial and temporal regulate protein able to create, trigger, enhances or repress the existent functions of the single components. Our long-term aim is to be able to study and control the complexity of the association between the modification and its substrates.
Early detection and cellular disintegration of α-synuclein aggregates using nanobodies